Program

The program provides a specific introduction to using genomic data in a biomedical laboratory. We split the course into morning sessions which introduce a topic with very applied and specific examples, highlighting just enough of the theory behind the tools to understand what's going on and how to choose parameters wisely. After the morning break, we will feature a lab scientist from our PGA or a collaborator to illustrate the use of genomics tools.

After lunch we will reconvene for a brief introduction into the assignments, followed by time to do the exercises on your laptop computer. Both wired and wireless network access will be provided. There will be staff on hand to answer any questions. There will be plenty of opportunity to work on your favorite gene(s) with experts to help you over hurdles.

Session Plan:

1. Basic sequence analaysis
   Brief overview of Lawrence Berkeley National Laboratory.
   Introduction to the PGA program.
   How to make sequence data useful? This session covers basic sequence analysis, sequence databases, and alignment tools.
2. Protein resources and tools
   Explore web-based tools for the characterization of protein sequence and structure using database, motif, and profile searching, as well as transmembrane prediction and multiple alignment tools.
3. Comparative genomics tools and SNP data analysis
   Learn to use the VISTA tools developed by the BerkeleyPGA to study conserved regions in cardiovascular genes.
4. Gene finding and genome annotation
   Learn about gene finding tools and their limitations. Look at annotated genome sequences. Given that you found your gene with lots of annotation, find out what you can do to expand and verify possibly conflicting annotation. Learn to use additional resources to build your confidence or distrust of the annotation.
5. Using microarray data
   Introduction into microarray technology and data analysis for comparative genomics. The second lecture will be about Biopathway databases and Protein Interaction data.

All sessions will be held in Perseverance Hall.

You may also want to look at recent Class pictures or watch the slideshow movie.

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