Mapping and Sequencing
- To provide multiple vertebrate sequence comparisons for HL&B genes
- To generate multiple primate sequence comparisons for 50 cardiovascular
disease related genes
Comparative Genomic Informatics
- To develop comparative genomic tools for multiple-species sequence
comparisons
- To build accessible computational tools for the analysis of sequence
comparisons between multiple closely related species
- To develop Human Enhancer Database
In Vivo Regulatory Element Analysis
- To assess the activity of conserved noncoding elements in driving
tissue expression patterns in transgenic mouse embryos
- To exploit the in vivo system for high throughput cis-regulatory
identification
Clinical Re-Sequencing
- To identify mutations causing idiopathic HL&B congenital disorders
by sequencing candidate genes in affected individuals
- To validate that putative variants identified in affected individuals
as causative mutations in genetically engineered mice
Education and Outreach Programs
- To conduct 2 to 3 hands-on courses per year targeted at biomedical
investigators on how to use computational genomic resources
- To publicize the databases and tools developed by the Berkeley PGA
through abstracts and presentations at appropriate biomedical meetings
- To develop tutorials for the bioinformatic resources generated
by the Berkeley PGA