A major means for characterizing noncoding conserved sequences identified through the sequencing and informatics component of this PGA is the generation of genetically engineered mice. Accordingly a variety of putative regulatory elements of genes of cardiovascular import have been or are in the process of being studied in mice. The following list includes genes that have been or are in the process of being studied:

Animals that have been generated are freely available to the general research community. Details about the structure of the genetic manipulations and steps to receive animals can be obtained by contacting Edward Rubin. Genes whose regulation is being studied in vivo and for which genetically engineered mice are or will be available:

• ApoAI, CIII, AIV, AV
  
• PPAR
  
• Apo(a)
  
• NKX2.5
  
• GATA4
  
• GATA6
  
• ABCA1
  
• SOST1
  
• ABCG5
  
• ABCG8
  
• LDL receptor